Illuminating Protein Signaling Dynamics in Intact Neuronal Circuits
Protein Biosensors & Brain Signaling
In the lab, we engineer and utilize protein biosensors to dynamically monitor protein signaling in the brain. By developing these tools, we can observe real-time molecular changes, offering unprecedented insight into neuronal activity and communication. Using this approach, we combine molecular, genetic and microscopy tools to better understanding how protein signaling shapes neuronal structure and function.
Targeting Neurological Disorders
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We specifically target vital protein signaling cascades associated with various neurological diseases, including developmental disorders, autism, and neurodegeneration. Our goal is to transform the fundamental understanding of protein signaling dynamics in a physiological state, ultimately identifying the root causes of protein dysfunction in brain pathologies.​